September 2018 Kentucky Lake Section Meeting
@
Union University
1050 Union University Drive
Jackson, TN 38305

Thursday, September 20th, 2018
Dinner @ 6:00 pm, Presentation @ 7:00 pm

All events will be held in the Carl Grant Events Center on campus
Directions and maps:  http://www.uu.edu/about/map/index.htm#Directions

From U.S. Highway 45 Bypass, take Union University Drive west to Walker Road. Turn left on Walker Road. The Grant Center is on your left after passing the Welcome House gate and student housing on the left.

Dinner: Choice of Greek Chicken or Beef Brisket, Salad, Cheesy mashed potatoes, mixed vegetables, and Chocolate Explosion with ice cream

Program: Learning to Abandon Assumptions and to Ask the Right Questions or A Mild, Metal-Free Method for the Synthesis of Fused Azaheteroaromatics

Dr. E. Blake Watkins, Professor of Medicinal Chemistry,
Union University College of Pharmacy

Bring your children to attend the Science Center!

Abstract:

Carbolines and fused-pyridine heterocycles are ubiquitous structural motifs prevalent in natural products, pharmaceuticals, agrochemicals, materials and ligand scaffolds, thus highlighting the significance of such structures. Among the isomeric α-, β-, γ-, and δ-carbolines, the most abundant framework in nature is β-carboline. β-Carboline-containing structures possess a wide array of pharmacological properties, including anti-inflammatory, anti-Alzheimer, antimalarial, antibacterial, antitumor, anti-HIV and others. Current procedures require multi-step syntheses or extended preparation of starting materials in order to prepare these isomeric structures.  Our interest in metal-catalyzed, C-H functionalization reactions compelled us to explore the synthesis of these agents in a much more economical manner, particularly in regard to the use of metal catalysts/additives and the number of synthetic steps.  The current status of this project and its application to the synthesis of a wide variety of variously substituted pyridines will be presented, with particular attention paid to agents of pharmacological interest

Speaker Biography:

Blake Watkins speaker photo

Blake Watkins serves as Professor of Medicinal Chemistry and Founding Chair of Pharmaceutical Sciences in the College of Pharmacy at Union University.  He completed his Bachelor of Science in Mathematics and Chemistry at Union and received his PhD in Chemistry from the University of Georgia under the direction of Professor Robert S. Phillips.  After doing postdoctoral work at the University of Mississippi School of Pharmacy in the Department of Medicinal Chemistry under Professor Mitchell A. Avery, he worked as a Research Scientist and Research Assistant Professor in drug discovery and natural products synthesis.  In 2008, he returned to Union to help start the College of Pharmacy.  His current research interests include synthetic method development with application to natural products and drug discovery.

 

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